CHICAGO -- Anthony Rizzo and Junior Lake each hit home runs and six pitchers combined for the shutout as the Chicago Cubs beat the St. Louis Cardinals, 3-0, to win their third straight and clinch their first series victory since last September.

Lake hit a two-run home run off Michael Wacha (2-3) in the sixth to give the Cubs a 2-0 lead. Starlin Castro led off the inning with a single and Wacha struck out Nate Schierholtz and Welington Castillo looking before Lake drove a 2-amd-1 pitch deep into the seats in left-center field.

Rizzo extended the lead to 3-0 in the eighth when he knocked the first pitch he saw from Randy Choate out in right field.

Brian Schlitter (1-0) went two-thirds of an inning to earn the win behind a strong start from returning Jake Arrieta for the Cubs, who had lost 14 straight series.

Hector Rondon pitched around two singles to start the ninth to earn his third save in as many opportunities.

The Cardinals (15-16) dropped below .500 for the first time since they were 3-4 to begin the 2013 season.

Lake's home run represented the only two runs Wacha gave up, one of five hits and three walks he allowed to go with six strikeouts over six innings.

Arrieta overcame a rocky start in his season debut to go 5 1-3 innings, giving up no runs, four hits and two walks with seven strikeouts. He gave way to Schlitter after 82 pitches, after giving up a single to Matt Adams.

Arrieta, who had been on the disabled list because of tightness in his throwing shoulder, found a groove after a pitching out of trouble in the first two innings, stranding two runners in both innings.

Arrieta got Yadier Molina swinging in the first to strand runners at the corners. After walking Matt Holliday with two out, Adams' single to left dropped in when Lake made a poor break on the ball.

After allowing the a single and a walk to start the second, Arrieta escaped trouble again. After striking out Greg Garcia, first baseman Anthony Rizzo threw out the lead runner at third on a bunt and shortstop Starlin Castro made an over-the-shoulder catch to take a hit away from Matt Carpenter.

NOTES: Cubs manager Rick Renteria successfully challenged a call at first base in the fifth inning. It initially appeared that the Anthony Rizzo came off the bag trying to dig out the throw from third. Renteria is 6-for-13 on replay challenges. ... Cubs OF Chris Coghlan was called up from Triple-A Iowa before the game. Renteria said Coghlan, the 2009 NL Rookie of the Year with the Miami Marlins, gives the Cubs flexibility in the outfield, and hinted that he would probably be used in left if needed. ... Manager Mike Matheny elected to start 2B Greg Garcia, who was called up from Triple-A Memphis on April 28, hoping he could "spark something" as the Cardinals try to find their offensive footing. ... Cardinals RHP Lance Lynn (4-1, 3.60 ERA) is scheduled to face RHP Jason Hammel (4-1, 2.08) in the series finale on Sunday at 7:05.